Inside Ennature Biopharma's supercritical-CO₂ extraction facility

Expertise

Extraction without compromise.

Two proprietary platforms solving the core challenges of botanical delivery — purity, solubility and bioavailability — at one of India's largest supercritical-CO₂ extraction facilities.

Technology Platforms

Cutting-edge science, end to end.

From supercritical extraction to advanced delivery, our platforms turn botanical actives into ingredients that are pure, soluble and bioavailable — engineered for the format you formulate in.

Supercritical CO₂ becoming a liquid-like solvent

Core Extraction Platform

Supercritical CO₂ Extraction

Solvent-free · closed-loop · green CO₂

Carbon dioxide pushed beyond its critical point becomes a highly selective, solvent-free medium — dissolving target bioactives straight from the plant with zero toxic residue. Low-temperature operation protects heat-sensitive phytochemicals, while a closed loop captures and recycles all CO₂.

Solvent residueZero
CO₂ recycled100% closed-loop
Zero solvent residueGreen sugarcane CO₂India's largest SCFE plant
SCEMOD™ nano-emulsion — oil dispersing into fine droplets

Lipophilic Delivery

SCEMOD™

True Oil Solutions

1,000×
Improvement in active solubility — shown with Xanthogreen® lutein esters (20% vs. 0.02%)

A proprietary platform that transforms lipophilic nutrients into True Oil Solutions — finely dispersed, highly stable nano-emulsions that raise solubility and bioavailability without heavy surfactant loading. Engineered for softgel and lipid-based delivery.

MechanismOil-in-water nano-emulsion
AbsorptionLymphatic route · bypasses first-pass
Best forSoftgels · lipid systems
Nano-emulsionsSoftgel-readyLow surfactant
LIMAN™ — actives dissolving into a water-soluble matrix

Water-Soluble Matrices

LIMAN™

Hydrophobic, made water-soluble

A groundbreaking platform that overcomes the challenge of delivering hydrophobic active molecules — converting them into water-soluble matrices that disperse cleanly in aqueous systems until a uniformly homogeneous solution is achieved, for higher bioavailability and optimised formulation.

MechanismWater-soluble matrix
BenefitIncreased bioavailability
Best forAqueous formats
GummiesBeveragesTabletsCapsules

Dehradun Facility

Advanced manufacturing, under one roof.

A single integrated site houses India's largest supercritical-fluid extraction plant alongside solvent refining, bio-fermentation, pilot and scale-up plants, and a full formulation facility — diverse, advanced technologies in one location for flexibility and end-to-end quality control.

SCFE PlantSolvent RefiningBio-FermentationFormulation

Quality & Compliance

Unwavering quality commitment.

End-to-end quality aligned with European pharmaceutical benchmarks — the same rigour applied to nutraceuticals as to regulated pharmaceutical actives.

Manufacturing

WHO GMP-COPP

Good Manufacturing Practice certification under the WHO scheme — the global benchmark for pharmaceutical-ingredient supply.

Quality Systems

ISO 9001:2015 · ISO 22000:2018

Dual certification covering quality management and food-safety management across nutraceutical and pharmaceutical operations.

European Compliance

EU-GMP / CEP

Sitewide EU-GMP audit passed; Certificate of Suitability granted by the EDQM for Thiocolchicoside and Colchicine.

Food Safety

HACCP Certified

Hazard Analysis and Critical Control Points — a systematic preventive approach to safety across all ingredient processing.

Market Access

Halal · Kosher

Third-party Halal and Kosher certification across the portfolio, supporting global market access.

Data Integrity

21 CFR Part 11

Full compliance with the FDA 21 CFR Part 11 quality system for electronic records and data integrity across operations.

Regulatory Dossiers

DMF / EDMF on File

Drug Master Files and European DMFs on record — enabling direct regulatory-submission support for US, EU and global markets.

Extraction Standard

SCF-CO₂ · Zero Residue

All primary extracts produced via supercritical CO₂, with analytical certificates confirming zero solvent residue for every lot.

Explore the portfolio

Technical dossiers, on request.

Ingredient specifications, technical dossiers and samples are available on request — our team supports regulatory review, label claims and custom formulation development.